Manuel de Sá (b. at Vila do Conde, Province Entre-Minho-e-Douro, 1530; d. at Arona, Italy, 30 December 1596) was a Portuguese Jesuit priest, theologian and exegete.

Restored to health, he returned to the Roman College, where he filled the chair of exegesis, and found time to give missions.

His reputation for scholarship induced Pope Pius V to appoint him as a member of the commission in charge of preparing the authentic edition of the Septuagint.

However short, Sá's annotations clearly set forth the literal sense of the Bible, and bespeak a solid erudition, despite a few inaccuracies which have been sharply rebuked by Protestant critics.

His theological treatise entitled Aphorismi Confessariorum ex Doctorum sententiis collecti (Venice, 1595), however remarkable, was censured in 1603, apparently because the Master of the Sacred Palace treated some of its maxims as contrary to opinions commonly received among theologians, but it was later corrected and has been removed from the Roman Index (1900).