Maria Manuela Machado (born 9 August 1963 in Viana do Castelo) is a former Portuguese long-distance runner, who was particularly successful when running the marathon.

She placed seventh in both the 1991 World Championships in Athletics in Tokyo and the 1992 Summer Olympics in Barcelona.

Machado won her first medal in a major competition in the 1993 World Championships in Athletics in Stuttgart when she came in second in the marathon.

She ran her personal best (2:25.09) in the London Marathon in 1999 (and was the third woman to cross the finish line).

Machado continued Portugal's successful run in the marathon that Rosa Mota had started.