[1][2] On September 9, 2005, at 16 years old, Lyrio broke the short-course South American record in the 4x200-metre freestyle relay, with a time of 8:01.78, along with Paula Baracho, Tatiana Lemos and Joanna Maranhão.

[3] At the 2007 Pan American Games, in Rio de Janeiro, Manuella got the bronze in the 4x200-metre freestyle, along with Monique Ferreira, Tatiana Lemos and Paula Baracho.

[17] In April 2015, participating in the Maria Lenk Trophy in Rio de Janeiro, she broke the South American record in the 4 × 200 metre freestyle relay with a time of 8:03.22, along with Joanna Maranhão, Larissa Oliveira and Gabrielle Roncatto.

[18] At the 2015 Pan American Games in Toronto, Ontario, Canada, Lyrio began earning a bronze medal in the 4 × 100 metre freestyle relay, by participating at heats.

[21] On the third day, she won the silver medal in the 4 × 200 metre freestyle relay, breaking the South American record, with a time of 7:56.36, along with Larissa Oliveira, Jéssica Cavalheiro and Joanna Maranhão.

[34] In the Women's 4 × 200 metre freestyle relay, she broke the South American record, with a time of 7:55.68, along with Jéssica Cavalheiro, Gabrielle Roncatto and Larissa Oliveira, finishing 11th.