[citation needed] Manzoor's father had migrated from Gurdaspur, Punjab, British India and came to live at Khairpur,[1] Sindh because of the ruling Talpurs, who were quite fond of his music.

He was honored with the title of "Bahar-e-Moseeqi" by Makhdoom Talib ul Mola at the Urs of Shah Abdul Latif Bhittai in 1960.

[3][1][7] In December 2010, Sindh Minister for Culture Sassui Palijo, paying tributes to Manzoor Ali Khan, called him the symbol and identity of Sindhi classical music.

He recalled that he could not forget the excellent performance of Manzoor Ali Khan at the wedding ceremony of brother of noted story writer Naseem Kharal.

He also said that Manzoor Ali Khan could sing, with equal mastery, poetry of almost all Sufi poets of Sindh including Shah Abdul Latif Bhittai.