Opened on June 18, 2006, the college was established by the Mapúa University in 2006 to expand its presence in Laguna, bringing its renowned engineering, maritime, and technological education to Southern Luzon.

[6] The institution's close proximity to the industrial hubs of Laguna provides students easy access to on-the-job training opportunities in prestigious companies in the country.

In fulfillment of the long-term development plan of Mapúa, a six-hectare land was acquired for its expansion and presence in Laguna, which stands as one of CALABARZON's industrial and commercial hubs.

Groundwork started in late 2005, and on January 23, 2006, Malayan Colleges Laguna (MCL) acquired its corporate personality following its registration with the Securities and Exchange Commission.

In November 2006, the Commission on Higher Education (CHED) granted approval to MCL to offer eight programs in the fields of Engineering, Information Technology, and Business.

To shelter the institution's growing community, the Albert Einstein Building was recently constructed, named after the scientist who, in his lifetime's work, exuded MCL's motto: Excellence and Virtue.

The collaboration focuses on offering students a distinctive education that emphasizes strategies for success, such as global immersion, hands-on experiential learning, cutting-edge facilities, and digital proficiency.

[9] In 2024, MMCL started to offer Bachelor of Science degrees in Aeronautical Engineering and Aircraft Maintenance Technology under the newly established Mapúa-Laguna Institute of Aviation (MIA).

[12] College of Nursing (CN) was also added, with the institute offering Bachelor of Science degrees in Medical Technology, Pharmacy, and Physical Therapy in partnership with Arizona State University.

To accommodate and create hands-on learning for students under the Mapúa-Laguna Institute of Aviation (MIA), MMCL has recently proposed the construction of a new facility named after Leonardo da Vinci.

[10] This certification confirms that MMCL's Educational Organizations Management System, which incorporates its program offerings, complies with the latest ISO 21001:2018 standards, demonstrating the institution’s commitment to prioritizing students' best interests.

Notable annual events include the MMCL Wizards Tournament, a sports festival where college students represent their respective departments in various competitions.