María Ángela Holguín Cuéllar (born 13 November 1963) is a Colombian politician and diplomat who has been serving as United Nations Secretary-General António Guterres’ Personal Envoy on Cyprus since 2024.

In 2010, while Holguín was serving as Colombia's Representative to CAF – Development Bank of Latin America and the Caribbean in Buenos Aires, the then president-elect Juan Manuel Santos Calderón nominated her to head the Ministry of Foreign Affairs.

Holguín's ambassadorship in Venezuela was overall seen as the tacit endorsement that enabled her to tackle the diplomatic détente between the sister nations, while her work with CAF signalled Santos' desire to strengthen ties with the rest of the continent.

Before having taken office, Holguín accompanied president-elect Santos on his first overseas trip after being elected, taking the diplomatic role head on during their meetings with British Prime Minister David Cameron and German Chancellor Angela Merkel.

[3] Holguín as Chancellor-designate also headed talks with Venezuelan Chancellor Nicolás Maduro that spearheaded the renewal of diplomatic ties with the neighbouring nation, which were later formalised in a meeting held in Santa Marta between the two Presidents.