[3] Her best remembered role is that of La Chilindrina, one of the main characters of the Televisa sitcom El Chavo del Ocho.

[citation needed] De las Nieves became famous as La Chilindrina in the Televisa sitcom El Chavo del Ocho.

[citation needed] In 1994, she was cast as the lead in Aquí está la Chilindrina, in which she lives in a convent with various nuns and orphan girls.

[citation needed] María Antonieta de las Nieves was able to win a legal battle over Chespirito in 2003, one that gives her permission to act as La Chilindrina in public whenever she wants to, and grants her rights over the character she played.

In November 2021, it was announced that de las Nieves and her character of La Chilindrina would be included in the Guinness World Records for being the actress "portraying the same role for the longest time (1971–2020).