[2] Botero began her acting career with production El Fantasma de Canterville (1971), alongside Carlos Benjumea, Maruja Toro, Enrique Pontón and Franky Linero.

Perhaps her most remembered characters are Yadira la Ardiente, from the telenovela Caballo Viejo, and Sándalo Daza, from Música Maestro.

[citation needed] Parallel to her career as antress, María Cecilia produced and starred in several musical comedies directed by her husband, the Argentine David Stivel (with whom he lived since 1981), now deceased.

[6] Her dream of popularizing musical theater in Colombia led her to make productions as important as Peter Pan, Sugar and La Mujer del Año.

[6] María Cecilia directs the Charlot Academy, an acting school created by her father, Jaime Botero.