She enrolled at the Universidad del Salvador, a Jesuit university in Buenos Aires, in 1985 and graduated with a degree in political science in 1990.

She entered public service in 1991 as an electoral history researcher at the National General Archives, later serving as an assistant in the Ministries of Education (1992) and the Interior (1993).

She contributed in this capacity to White Helmet missions in the Gaza Strip (youth sports); Honduras and Nicaragua (health crisis management in the aftermath of Hurricane Mitch); Bolivia (Chagas disease mitigation); Paraguay (family farming); and Argentina itself (flood relief).

[1] Rodríguez served in this post until 1999, and was made a member of the United Nations Disaster Assessment and Coordination (UNDAC) in April of that year.

She was appointed Secretary of Military Emergency Assistance Coordination in May 2013, and in December of that year was nominated by President Cristina Fernández de Kirchner as Minister of Security.