María Dolores de Aycinena y Micheo (29 October 1814 – 29 May 1874) was a Guatemalan woman.
She was the wife of Acting President Pedro de Aycinena y Piñol, First Lady of Guatemala during his government in 1865.
She was daughter of José Aycinena Carrillo and Mariana Micheo Delgado Nájera.
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