"Antes muerta que sencilla" won the competition becoming the Spanish entrant, and María Isabel the performer, for Junior Eurovision.

"Antes Muerta que Sencilla" became an instant radio hit in Spain, and was later promoted in Latin America, where María Isabel's album was released in 2005.

In April 2005, she was interviewed on American nationwide television for the first time, when she was presented on Univision's El Gordo y la Flaca and chatted with hosts Lili Estefan and Raúl De Molina.

In November 2009 she released her fifth album, Los Lunnis con María Isabel, which contained the songs from the show as well as two original tracks.

After a career hiatus in order to finish her studies, María Isabel returned to music in 2015, eleven years after her debut, with her sixth studio album, Yo Decido.

[9] She took part in the televised national final organised by Televisión Española with a song composed by David Santisteban and titled “La vida sólo es una”,[10] the first single from Yo Decido.

[12] In April 2024, it was reported that RTVE had started negotiations with María Isabel to be a guest or host the contest on the occasion of the 20th anniversary of her victory in 2004.