María Isabel Rodríguez (born November 5, 1922) is a Salvadoran physician, academic, and government official.

[1][2] She earned her medical degree from the University of El Salvador in 1949 (despite being warned by the dean against joining such a "man's profession").

[1] In 1954, she returned to her alma mater and began a career as cardiovascular physiologist and biomedical researcher.

[3] She left El Salvador in 1972 after the university faced military intervention (part of the run-up to the Salvadoran Civil War).

[1][9] From 1985 to 1994, she worked as a consultant for the International Health Training Program, based in Washington, D.C.[1][9] In 1994, Rodríguez returned to the University of El Salvador as an advisor and professor in the Faculty of Medicine.