María José Portillo Ramírez (born 8 May 1999) is a Mexican tennis player.

She has career-high WTA rankings of 377 in singles and 229 in doubles.

Portillo Ramírez has won two singles titles and 18 doubles titles at tournaments of the ITF Women's Circuit.

Playing for the Mexico Fed Cup team, she has a win/loss record of 3–1.

This biographical article relating to Mexican tennis is a stub.