She began her artistic career at eight years in the program Teatro Fantástico with Enrique Alonso "Cachirulo".

[4] She also participated in the successful telenovelas Cuando llega el amor, in 1990; La antorcha encendida, in 1996 (in which she played the role of Josefa Ortiz de Dominguez; Te Sigo Amando [es], in 1996; Alborada, in 2005–2006; Mañana es para siempre, in 2008–2009; and recently Corazón Salvaje, in 2009–2010 and returns to the telenovela in 2014, Hasta el fin del mundo.

Rojo also participated in Mexican TV Series such as: Mujeres Asesinas, in 2008–today; and Gritos de Muerte y Libertad [es], in 2010, as well as in many theatre plays.

Maria Rojo was federal deputy in the LVII Legislature of the Congress of the Union in the lower house 1997–2000.

She left office April 4, 2003, to compete for a position in the Legislative Assembly of the Federal District (legislature in Mexico City).