Her father, John Simon Padrós, was an engineer, a prominent politician and industrialist; her mother was Emilia Dublé.

At the age of 20, Simón studied sculpture with Jean Labourdette and five years later, with Libero Badíi.

In 1964, she obtained a grant awarded by the British Council and moved to London, where she exhibited at the Institute of Contemporary Arts (ICA).

She also participated in the Venice Biennale (1972), Biennale of Tapestry in Lausanne, Biennials of Engraving at Ljubljana and in Puerto Rico, the First International Sculpture Street Exhibition in Santa Cruz de Tenerife, and the Basel Fail.

She used lead, resin, acrylic, textiles, cardboard or wood in her works.