From 1995 to 2018, Antongiorgi-Jordán was a partner at McConnell Valdés in San Juan, Puerto Rico.

Antongiorgi-Jordán started her career as an attorney in 1995, and later became a Capital Member of the Labor and Employment Law Practice Group.

President Biden nominated Antongiorgi-Jordán to the seat vacated by Judge Gustavo Gelpí, who was elevated to the United States Court of Appeals for the First Circuit on October 19, 2021.

[4] On July 13, 2022, a hearing on her nomination was held before the Senate Judiciary Committee.

[6] On November 14, 2022, the United States Senate invoked cloture on her nomination by a 51–43 vote.