The museum was founded by the Vitebsk City Executive Committee's decision on October 23, 1991.
Exhibitions of graphic works by Chagall from the museum's collection are held here: woodcuts, etchings, aquatints, a series of illustrations of Nikolai Gogol's novel "Dead Souls" (1923-1925), a series of color lithographs from 1956 and 1960 on the theme of the Bible, a cycle of colour lithographs entitled The 12 tribes of Israel (1960) and other of his works.
The museum also houses a collection of printed graphics by European avant-garde artists such as Joan Miró, Pablo Picasso and Fernand Léger.
The Art Center has a scientific library dedicated to the works of Chagall and other avant-garde artists, which has more than 3500 volumes.
The Marc Chagall House-Museum, at 11 Pokrovskaya Street, was opened in 1997 and is located in the house built by the artist's father in the early 1900s.