During his career, he played for the National Hockey League's Columbus Blue Jackets, Ottawa Senators, and Dallas Stars.

Methot made his professional debut during the 2005–06 season with the Syracuse Crunch, Columbus' then-American Hockey League (AHL) affiliate.

An assortment of injuries limited Methot's effectiveness with the Blue Jackets, most notably a mandibular fracture suffered during the 2011–12 season.

After starting the season paired with Norris Trophy-winning defenceman Erik Karlsson, Methot was charged with the responsibility on anchoring the team's defense after his partner was lost to an Achilles injury.

Methot later returned in the post-season to help the Senators reach the Eastern Conference Finals, where he lost in 7 games to Crosby’s Pittsburgh Penguins.

[3] With the Senators unable to work out a trade to prevent his selection, he was chosen by the Vegas Golden Knights on June 21, 2017.

[4] Just five days later, on June 26, Methot was traded by the Golden Knights to the Dallas Stars in exchange for Dylan Ferguson and 2020 2nd-round pick.