[10] During the 2009 outbreak of Swine flu, Siegel was a proponent of administering Tamiflu to children at summer camps "where there have been large, confirmed outbreaks" in order to stop the spread; Siegel said that he respectfully disagreed with the CDC's guidance to limit the use of Tamiflu in camps when lives could be saved with more aggressive treatments.
[14] In a March 2020 appearance on Fox News's Hannity, Siegel stated that, based on the declining case count in China at the time, COVID-19 "should be compared to the flu.
"[22] In August 2021, Siegel advocated for wider availability of booster shots as a means to provide enhanced protection to broader groups.
The Wall Street Journal reviewed it, stating "Dr. Siegel’s chief argument is hard to dismiss: that fear, encouraged by a news media obsessed with doom and misery, has impelled public-health experts ... to impose draconian policies and ordinary Americans either to exaggerate or ignore moderately serious problems like Covid-19.
[12][26][27] During the 2022–2023 mpox outbreak, Siegel praised the U.S. CDC for making changes to public health guidance that increased the likelihood of controlling the virus.
[29] Following the on-field cardiac arrest of Damar Hamlin and his subsequent recovery, Siegel compared the power of positive stories to unite the country with the divisiveness of DC politics, in particular the fight over the election of House Speaker Kevin McCarthy.
[31] In 2017, Siegel wrote an op-ed in The New York Times that criticized the ACA and its essential health benefits provision (which he described as "an overstuffed prix fixe meal filled with benefits like maternity and mental health coverage") and praised the Republican legislation to repeal the ACA.
[32] During the repeal debate, Siegel supported Republican legislation that would limit "the menu of essential benefits" and instead create subsidized "high-risk pools" for uninsured patients with pre-existing conditions, although he also opposed "drastic cuts to Medicaid" supported Medicare expansion based on the success shown in Indiana and Ohio, and urged increased interstate competition for insurers.
The interview was praised by the Columbia Journalism Review as prompting a "six-minute meander through Trump’s thicket of self-diagnosis, during which the president mentioned China, Russia, Ukraine, judicial appointments, the Twenty-fifth Amendment, and, most notably, his ability to recite a string of five words while under observation by medical experts.
[36] In Fox News appearances during the 2016 U.S. presidential campaign, he urged the release of health records of candidate Hillary Clinton, in order to evaluate her physical fitness for office.
Siegel has repeatedly ridden with President George W. Bush in his Warrior 100k annual three-day mountain bike ride, where they discussed the role of endurance exercise in healing physical wounds and behavioral challenges.
In The Inner Pulse: Unlocking the Secret Code of Sickness and Health (2011),[44] Siegel describes medical miracles and posits a perceptible but ineffable and immeasurable "essential life force" "where the physical and the spiritual combine," advising readers to engage in practices to strengthen and focus it for use in overcoming disease and healing.