Marcello Puglisi (born May 17, 1986 in Trescore Balneario) is an Italian racing driver.

In 2003 and 2005 he competed in a total of six Eurocup events, failing to score any points in the process.

Puglisi also drove in a single round of the Le Mans Series in 2007 for the Scuderia Lavaggi team in the LMP1, scoring no points.

Puglisi was signed by the Piquet Sports team to drive in the first GP2 Asia Series season for 2008.

Having committed to another season of Formula Master, he nevertheless took his opportunity to compete in the 2008 GP2 Series proper as a replacement for Davide Valsecchi in the Durango team, who was injured in a high-speed crash at the second round of the championship in Turkey.