Born in Brescia, he has previously played in Serie A for Verona, Lecce and Roma and in England with Watford.

[3] Cassetti started his football career at Montichiari, an amateur-level club inside the province of Brescia.

[8] On 23 August 2012, Cassetti signed for Udinese on a one-year deal, agreeing to join Watford on a season-long loan on the same day.

Udinese did not publicise their signing of Cassetti, meaning that it was a move purely for the benefit of the English Championship club.

[9][10] In June 2013, Cassetti signed for Watford permanently and scored his first goal for the club in a 3–3 draw at home to Blackburn Rovers on 25 March 2014.

He played his last game for Italy in a 2008 2–1 over Cyprus in 2010 FIFA World Cup qualification, under Marcello Lippi.