Born in 1965 in Rome and passionate about television since he was a child, Marco Liorni obtained a classical high school diploma and a degree in humanities.

He later became a face of the television station GBR with Cronaca near (inspired by Telefono giallo, by Corrado Augias) and Domenica a tutto goal together with Monica Leofreddi and Cristina Bianchino.

From 1997 to 2000 he hosted the television programme Angeli, a sort of investigation into spirituality through the stories of people who feel they have come into contact with something they cannot explain rationally and which they often attribute to angels.

In 2000 he was a correspondent for the television programme Grande Fratello, the "charon" who ferries people who were previously unknown to the TV, then recounting the experiences and the consequences of the sudden fame in the families of the contestants.

on Canale 5, a reality show in which a man or a woman puts their partner under pressure by asking to be married immediately, with a promise of marriage on live TV.

The program, produced by Endemol Italia, was a good success with the public, but the same production company sold it to Rai instead, where it ran two series hosted by Antonella Clerici.

In 2006, he presented on Mediaset Premium, assisted by Platinette, the programme Il Candidato, which allows the live selection of one of the contestants of the seventh edition of Grande Fratello.

In 2010 he hosted and wrote the sixteen episodes of Tra cielo e terra, the programme dedicated to the most beautiful abbeys and fascinating monasteries in Europe, broadcast on the Marcopolo satellite channel, which at the time was part of the Sky platform.

In the 2015/2016 season, he was once again at the helm of La vita in diretta together with Cristina Parodi and in prime time on Rai 1 he hosts the entertainment television programme Il dono with Paola Perego.

He began the new 2024/2025 television season by hosting the pilot episode of the game show Chi può batterci?, broadcast in prime time on Rai 1 on Saturday, 21 September 2024,[5][6] while from 3 November, he returns to the helm of the twenty-third edition of L'eredità.

In 2014 he married in the United States of America his second wife Giovanna Astolfi,[7] with whom he had daughters Emma and Viola; the marriage was made official in Italy in 2016.