Mengoni reached commercial success in Italy when his first single, "Dove si vola", released after he won the third series of Italian talent show X Factor, debuted at number one on the FIMI Top Digital Downloads in December 2009.

In 2013, Mengoni released the single "L'essenziale", which won the 63rd Sanremo Music Festival and represented Italy in the Eurovision Song Contest.

The albums spawned several singles, including the Italian number-ones "Guerriero" and "Ti ho voluto bene veramente".

Mengoni's fifth studio album, Atlantico, was released in 2018 and featured the single "Hola (I Say)", a duet with Scottish singer Tom Walker.

The project included multi-platinum singles "Mi fiderò", featuring Madame's vocals, and "Ma stasera".