[17] On 29 September, Reus scored two goals for Dortmund in a 5–0 rout of his former club Mönchengladbach, pushing the champions to the top of the Bundesliga table through six games.

[19] He then opened the scoring for the German champions in their 2–2 draw with Real Madrid at the Santiago Bernabéu Stadium on 6 November, netting on a spectacular volley against Iker Casillas, after a kick-down from teammate Robert Lewandowski.

[27] On 27 July 2013, in the 2013 DFL-Supercup against Bayern Munich, Reus netted the game's opening goal and later rounded off the scoring, as Borussia Dortmund claimed a 4–2 victory to lift the trophy.

[30] On 25 February 2014, Reus scored a goal in a 4–2 win for Dortmund against Zenit Saint Petersburg in the first leg of the round of 16 in the UEFA Champions League.

[34] At the beginning of the season, Reus was not part of the squad that won the 2014 DFL-Supercup with 2–0 over Bayern Munich, due to the lack of fitness after having returned from a partial tear of the syndesmosis.

Reus and his team would lose 3–1 against league runner-up Wolfsburg at Olympiastadion, failing to win his third final with the club and thus his first major trophy.

On 5 August 2015, Reus scored a goal in Borussia Dortmund's 5–0 win against Wolfsberger AC to advance into the 2015–16 Europa League play-off round.

[53] On 19 April 2017, Reus scored in the second leg Champions League quarterfinals match in a 3–1 (6–3 on aggregate) loss against AS Monaco, failing to qualify for the final four of the competition.

[66] On 21 August 2018, Reus scored the winning goal in extra time to help his side earn a 2–1 victory over SpVgg Greuther Fürth in the DFB-Pokal first round match.

[75] He would go on to win the DFB-Pokal for a second time in his career by the end of that season, after a one-sided 4–1 victory over RB Leipzig, in which he provided two assists to Erling Haaland and Jadon Sancho.

[77] On 3 March 2023, Reus scored in a 2–1 victory over RB Leipzig, to become the joint second all-time goalscorer for Borussia Dortmund along with Michael Zorc with 159 goals.

[85] Three days later, Reus played in his 400th match for Borussia Dortmund in all competitions in Der Klassiker against Bayern Munich, to be the sixth player to achieve this milestone, only behind Michael Zorc, Mats Hummels, Roman Weidenfeller, Stefan Reuter and Lars Ricken.

On 24 March 2024, Reus scored his second goal of that season's Champions League campaign, a second leg round of 16 match against PSV Eindhoven, which ended in a 2–0 home victory (3–1 on aggregate) for Dortmund.

[87] A week later Reus would be part of a 2–0 away victory at Allianz Arena against Bayern Munich, making a crucial step towards securing Champions League spots for the following season.

[91] On the final matchday of the 2023–24 season, he scored a free-kick goal and provided an assist in a 4–0 win over Darmstadt at the Signal Iduna Park, his last ever match on homesoil.

[92] On 1 June, in the Champions League final, he played his last match for the club against Real Madrid, who had beaten Bayern Munich prior, which ended in a 2–0 defeat for Dortmund, once again at Wembley Stadium.

On 15 August 2024, Major League Soccer club LA Galaxy confirmed the signing of Reus on a two-and-a-half year contract.

[97] On 7 December 2024, Reus and his squad won the MLS Cup with a 2–1 win against Eastern Conference champions New York Red Bulls for the first time in ten years, also marking his first ever league title of his professional career.

[102] Three days before the match, he withdrew from the squad due to a leg injury picked up in the last game of the season against Bayer Leverkusen, which forced him to miss the 2010 FIFA World Cup in South Africa.

[108] Reus established himself as a regular member of Joachim Löw's side in the 2014 FIFA World Cup qualification campaign, scoring five goals and registering three assists in six matches.

[109] He was named in Germany's squad for the World Cup finals, but was ultimately forced to withdraw after suffering an ankle injury in the team's last 6–1 warm-up win against Armenia on 6 June.

[110] Shkodran Mustafi would fill his empty spot in the squad and Reus would miss his team winning the trophy for the fourth time in their history.

Reus made his international comeback in Germany's first post-World Cup friendly against Argentina on 3 September 2014, whom they had beaten in the final two months prior.

[111] From then on, Reus would wear the shirt number 11, previously worn by Miroslav Klose, who retired from the national team after the World Cup.

During qualification for UEFA Euro 2016, Reus made four appearances, scoring once in a 2–0 victory over Georgia in Tbilisi, but was not selected for the tournament after suffering a groin injury.

[112][113] On 2 June 2018, Reus made his return to international duty after two years in a friendly match against Austria, which ended in a 2–1 loss for Germany.

[121] In November 2022, Reus was exempt from Hansi Flick's 2022 FIFA World Cup squad reportedly as a result of an ankle injury he suffered in a match against Schalke, which he failed to recover from in time.

[122] In October 2023, Reus showed interest to become part of the squad to represent Germany at the UEFA Euro 2024 on homesoil, and did not rule out a participation at the tournament should there be no physical complications.

[155] He had been driving for years with a fake Dutch licence,[156] a felony in its own right,[157] and has been issued with speeding tickets on at least five occasions since 2011 without authorities knowing that he was not legally licensed.

The felony charges for using a counterfeit licence were later dropped, causing some controversy and raising questions from politicians whether his celebrity status had been a reason for a milder sentence.