In August 2012, he took up the position of head coach of Budapest Honvéd FC where he served in two spells.

In 2017, he signed a two-year contract with FC DAC 1904 and since 19 June 2018, he has served as the manager of the Hungary national team.

Growing up in the Torino youth academy, with whose Primavera team he won an Italian Cup and a Viareggio Tournament, he made his Serie A debut in the 1983-1984 season in Torino-Ascoli (0-0) on March 18, 1984.

When his contract with the Genoese club expired, at the age of 31, he moved abroad, first to Mexico to América, then to Germany to Eintracht Frankfurt.

In 1997 he returned to Italy to end his professional career at Piacenza, with which he won salvation in Serie A in a season conditioned by repeated injuries.

[2] On 7 February 2015, Rossi was appointed as the coach of the Nemzeti Bajnokság I club Budapest Honvéd FC for the second time in his career.

In the final round of the season, DAC beat Ružomberok 4-0 away from home to secure their place on the podium, while Rossi led another team to the Europa League qualifiers after bronze medallist Honvéd.

[13] Since Greece lost to Estonia at home,[14] Hungary finished second in their group and their chances to qualify for the UEFA Euro 2020 remained alive.

In the UEFA Euro 2020 qualifying play-offs, Hungary were drawn in Path A along with Bulgaria, Romania, and Iceland.

[20] One day before the national team's decisive Euro 2020 qualifiers play-off match against Iceland, Rossi was tested positive for COVID-19.

[26] In the 2022–23 UEFA Nations League series, Rossi's Hungary were drawn in one of the most difficult groups including Italy, England, and Germany.

[30] On 31 October 2022, a detailed interview with Rossi was published by Nemzeti Sport entitled Success in Hungary has changed my life.

[31] During the interview, it was also leaked that a film would be created on Marco Rossi coaching the Hungarian national team.

[32] A week later, on 8 November, Rossi said that Balázs Dzsudzsák deserved a farewell match so he invited him to the squad against Greece.

[34] On 16 November 2023, Hungary secured their qualification to the UEFA Euro 2024 on top of their Group G, following a 2–2 away draw against Bulgaria.

[37] However, Hungary could win their last group match against Scotland thanks to a late goal by Rossi's substitution, Kevin Csoboth.