He gained national prominence in 2016–17 season as a redshirt junior while at Central Michigan University, having been profiled by Sports Illustrated, the NCAA, and ESPN because of his prolific scoring ability.

In 2014–15, his season was "up and down," but he performed well by averaging 15.6 points per game, which led the team and was sixth-highest in the Horizon League.

In 2015–16, Keene had to sit out his first season at Central Michigan due to NCAA transfer eligibility rules.

Through YouTube-worthy highlights, SportsCenter Top 10 game-winning shots, and his nation-leading scoring average, sports media have paid attention to him.

[2][3][4] On January 21, 2017, Keene scored 50 points against Miami (Ohio), including 10 made three-point field goals.

[14] On March 1, 2019, Keene signed with the KCC Egis of the Korean Basketball League (KBL).

Keene returned to Sideline Cancer in 2020 and was the catalyst behind it advancing to its first TBT championship game.

[16] Keene signed with Yulon Luxgen Dinos of the Super Basketball League in Taiwan.

[18] On July 4, 2021, Keene signed with KK Cedevita Olimpija in the top tier Slovenian Basketball League.

[24] On November 5, 2024, Keene signed with Maroussi of the Greek Basketball League (GBL) and the FIBA Europe Cup (FEC).