[1] Since 2003, he has been lecturing at the Department of Political Science and International Relations of the Faculty of Philosophy of the University of West Bohemia, where he received his doctorate in political science in 2006,[1] and since 2008 also at the Prague Metropolitan University.

[4] From 2005 to 2009, Ženíšek was a member of the Christian and Democratic Union - Czechoslovak People's Party (KDU-ČSL).

[6] Ženíšek was re-elected vice-chairman at the second TOP 09 National Assembly on 22 and 23 October 2011 in Hradec Králové,[6] and the third in Prague on 8 December 2013.

He was involved in the beginning of the long-term project to reform psychiatry in the Czech Republic.

[8] He resigned as First Deputy Minister of Health following the inauguration of Jiří Rusnok's government on 1 August 2013, saying he could not imagine continuing at the ministry while also vice-chairman of TOP 09.

[14] During the 2019 European Parliament election in the Czech Republic, Ženíšek ran as a member of TOP 09 in sixth place on the candidate list "Mayors (STAN) with regional partners and TOP 09", but was not elected.