[1] Frame graduated with a first class honours BSc in Biochemistry, followed by a PhD from the Medical Faculty, at the University of Glasgow.
[2] Margaret Frame worked for a brief period in industry, before joining the MRC Virology Unit in Glasgow as a post-doctoral scientist.
In 1995, she was jointly appointed as Professor of Cancer Research in the Faculty of Biological Sciences at the University of Glasgow and the Beatson Institute, where she became Deputy Director in 2002.
[2] Margaret Frame’s long-held research interests are in cancer invasion and metastasis, and the role of tyrosine kinases in controlling tumour cell spread.
Her main goal is to work with clinicians treating cancers of unmet need, to determine whether targeting the invasive and metastatic processes may be of therapeutic benefit, and may be monitored in the preclinical and clinical settings by novel imaging techniques.
Typically, these proteins regulate a variety of processes that lie at the heart of cancer, epithelial plasticity, epithelial to mesenchymal transition (EMT), loss of tissue regulation and tissue architecture, self-renewing properties, resistance to therapy, invasion and metastasis and host-tumour interactions.