Margaret Frances Guy, OBE (born Martha Fanny Looker; 14 October 1910 – 25 August 1988) was at the time Australia's youngest hospital matron.

Born Martha Fanny Looker in Hobart, Tasmania, on 14 October 1910, she was the daughter of New Zealand-born Martha Fanny (née Smith) and English pastry cook Edward William Looker.

Her father's business failed in 1917 leaving the family poor and living in the Sydney suburn of Normanhurst.

When she left in 1945, after serving in the Middle East, Papua New Guinea and in the Solomon Islands, she held the rank of captain.

The others were Georgina McCready, Muriel Knox Doherty and Agnes Mary Lions.