She was engaged in religious work in Brooklyn, and for more than a quarter of a century, she gave Bible talks to the society women of New York City.

[2] About 1876, she commenced giving Bible talks in drawing-rooms to society women of New York City and continued this practice for more than 25 years.

Bottome was a pastor in the wealthy suburb of Tarrytown, New York, some of the summer residents heard of the talks Margaret was giving to a class which she led, and they came to listen to her.

After that, for more than a quarter of a century, she lectured on the topic of "Bible Talks" in the drawing rooms and salons of wealthy women;[7] it was her most effective personal work.

Among her other published works are Crumbs from the King's Table, A Sunshine Trip to the Orient, Death and Life, and Seven Questions After Easter.

[1] Some of Bottome's lectures, her "Bible Talks" , were published first in the Silver Cross Magazine, the organ of the King's Daughters, and later in book form, under the title of The Guest Chamber (New York, 1893).

[2] The Margaret Bottome Memorial, The King's Daughter's House in Harlem (incorporated, 1907), was located at 344 East 124th Street, New York City.

It focused upon settlement lines in the Upper East Side districts, and maintained a sewing school, clubs, classes, and fresh-air work.