The Margaret Sanger Clinic is a historic building at 17 West 16th Street in Manhattan, New York City.

[2][4][5] The former Margaret Sanger Clinic site is located between Manhattan's Chelsea neighborhood and Union Square, on the north side of West 16th Street between Fifth and Sixth Avenues.

The interior of the building retains many original Greek Revival features, including fireplace surrounds, marble floors, and a winding main staircase.

It was next quartered in rented rooms on West 15th Street, and purchased this building in 1930 as its first permanent home.

Sanger and her clinic were instrumental in fundamentally altering how Americans talked about sex, venereal diseases, and contraception.