Margaret of Brunswick-Lüneburg (6 April 1573 – 7 August 1643), was a German member of the House of Welf and the Duchess of Saxe-Coburg by marriage.

Margaret married John Casamir, Duke of Saxe-Coburg in Coburg on 16 September 1599, becoming his second wife.

Most of the wedding guests stayed before and during the marriage festivities at Heldburg Castle.

John Casimir celebrated his marriage with the famous Coburg Taler: on the obverse showed a kissing couple with the inscription WIE KVSSEN SICH DIE ZWEY SO FEIN (A well kiss between two), while on the reverse, showed a nun with the inscription: WER KVST MICH - ARMES NVNNELIN (who kiss you now, poor nun?).

Margaret returned to her homeland, Celle, where she died ten years later, aged 70.