Margaret did not support the idea of deposing Queen Mary of Hungary and discouraged her husband from doing so.

[3] In the meantime, relationships with Pope Urban VI became strained, as he suspected that Charles was plotting against him.

In 1387 she poisoned her elder sister Joanna, Duchess of Durazzo, who might have a better claim to the throne of Naples, and her husband Robert IV of Artois, Count of Eu to death.

[4][5] Pope Boniface IX and Margarethe came to a peace agreement, her excommunication was lifted and with the help of Cardinal Angelo Acciaioli Margaret could continue to serve as regent until July 1393.

In the last years of her life, the queen dowager retired first to Salerno and then to Acquamela, where she died of plague in 1412.