Margaret of Guelders (11 August 1436, Grave, North Brabant – 2 November 1486, Simmern) was a noblewoman from what is now the Netherlands.
She was married to the Count Palatine of Simmern and was the Countess of Palatinate-Simmern.
She was the daughter of Arnold of Egmond, Duke of Guelders, and Catherine of Cleves (1417–1479).
In Lobith, Gelderland, on 6 August 1454 she married Frederick I, Count Palatine of Simmern making her Countess of Palatinate-Simmern.
They had ten children: She died on 2 November 1486 at Simmern unter Dhaun, Bad Kreuznach, Rhineland-Palatinate, Germany, and she was buried at Kloster Ravengiersburg a monastery in the now Germany where her husband too was buried.