Margarete of Saxony (4 August 1469 in Meissen – 7 December 1528 in Weimar) was a Saxon princess of the Ernestine line of the house Wettin by birth and by marriage a Duchess of Brunswick-Lüneburg.

Her brothers Frederick the Wise and John the Steadfast were Electors of Saxony; her sister Christina was Queen of Denmark.

Margarete married on 27 February 1487 in Celle with Duke Henry I of Brunswick-Lüneburg (1468–1532).

Marriage negotiations presumably began in 1469, as Henry's father, Otto V had formed an alliance with Margarete's uncle William.

Margarete died in 1528 and was buried in the Church of St. Peter and Paul in Weimar.