Kane grew up with an abusive and overly strict stepmother, and eventually found herself alienated from her family later on.

By the age of twenty, Kane had taken up residence on Skid Row, was living off social assistance, and was dependent on drugs and alcohol.

Eventually, Kane was able to disentangle herself from her substance abuses, and move away from Skid Row and enroll in Edmonton’s Grant McEwan College (MacEwan University) for performing arts; it was here that she excelled in dance, acting, and singing.

Her performance at McEwan College led to scholarships with Banff School of Fine Arts and Circle in the Square Theatre Company in New York.

Margo received national attention during the late 1970s with the play The Ecstasy of Rita Joe by George Ryga, performed at Citadel Theatre in Edmonton Alberta.

Margo has also involved herself with a national youth caravan which brought theatre to small Native communities across Canada.

It was around this time that she landed a small part on the CBC's First Nations TV series, Spirit Bay, in which she was cast as the school teacher.

Full Circle puts on an annual event called Talking Stick Festival, which hopes to "establish a unique showcase for talented, emerging and professional artists, to engage Aboriginal cultural communities, and to introduce Vancouver's many audiences to contemporary Aboriginal artistic practices.".

Kane's use of solo-voice mixes various techniques and styles of theatre including storytelling, ritual, dance, and mime.

Later, in the 1960s she joins many others hitchhiking across America and in that journey she begins to discover the authentic voice inside her that had been silenced but never lost.

- Jane Emson, The Kamloops Daily News "Kane's storytelling is innately theatrical, her superb physicalization explanation of events and the colourful characters she meets on her journey places this production at the very top echelon of the solo-performer format.