In 1946 she became a founder of the Verband Weiblicher Angestellter (VWA, "Association of Women Employees") having been active in a predecessor organisation since 1933.

She belonged briefly to the Executive Board of the Bundesversicherungsanstalt für Angestellte ("Federal Insuranceoffice for Employees") and in the 1950s, was a member of the Advisory Council for Reorganisation of Social Services at the office of the Ministry of Labour.

Together with Ernst August Farke she represented the Arbeitnehmerflügel ("Worker's Wing") of the German Party in parliament.

Unlike most women in her party, Margot Kalinke opposed the "Stitch Ruling" (pertaining to the rights of the husband in marital disputes).

The Gesetz über die Gleichstellung von Mann und Frau auf dem Gebiet des bürgerlichen Rechts ("Law of Equality between Man and Woman in Civil Law") was enacted on 18 June 1957 without the Stitch Clause.