Margot began her career in 1975 working in theater (Godspell) and television commercials and was a member of the original company of I'm Getting My Act Together & Taking it on the Road at the New York Shakespeare Festival, then later at the Circle in the Square Downtown.
Rose has had a number of roles in films, including: 48 Hrs., A Civil Action, True Believer, Brewster's Millions and Hollow Man.
She also performed in the original Del Shores stage production of Sordid Lives in 1996[2][3] in the role of Bitsy Mae Harling.
[4] [7][8][9][10] Of Rose's performance in the theatrical production of The Gay '90s Musical in 1997, Variety wrote the play "features the beautifully harmonized voices of Margot Rose, [Bill] Ledesma and [Bill] Hutton as a trio of gay friends who nurture and support each other throughout their lives".
[6] Of her performance in the 1996 theatrical production Sordid Lives Variety wrote "Also lending solid support are ... and Margot Rose as the well-worn Betsy Mae, whose gentle musical offerings of such ballads as 'Will the Circle Be Unbroken,' 'The Water Is Wide' and an original title song punctuate the onstage doings.