Maria Domenica Mantovani (12 November 1862 - 2 February 1934) was an Italian Roman Catholic professed religious, and the co-founder of the Little Sisters of the Holy Family; she established them alongside Giuseppe Nascimbeni.

[2][5] On 8 December 1886, she made a private vow to remain chaste and asked the Blessed Mother to guide her in how best to fulfill her vocation.

[4] In 1892, she founded a religious congregation alongside Nascimbeni and became its first superior; she led the order for a total of four decades.

On 24 April 2001, Mantovani was proclaimed to be Venerable after Pope John Paul II approved her life of heroic virtue, both cardinal and theological.

"[6] The second miracle attributed to her – required for her canonization as a saint – was investigated in Bahía Blanca from 16 November 2015 until 10 June 2016; Cardinal Antonio Cañizares Llovera presided over the closing of the diocesan process, alongside the vice-postulator and medical experts.

On 27 May 2020, Pope Francis authorized a decree during a meeting with the prefect of the C.C.S., Cardinal Giovanni Angelo Becciu, which approved a miracle, clearing the way for Mantovani to become a saint.