Maria Euphrosyne was born at Stegeborg Castle, Östergötland, to Count Palatine John Casimir of Zweibrücken and Princess Catherine of Sweden.

Maria Euphrosyne had a close relationship with her brother Charles, and did what she could to support his planned marriage with Christina.

At the coronation of her brother King Charles X Gustavus in 1654, Maria Euphrosyne was granted the rank and status of a Royal Princess of Sweden.

During the Dano-Swedish War (1658-1660), she and her sister-in-law Queen Hedvig Eleonora lived at Kronborg in Denmark after it had been taken by the Swedish general Carl Gustaf Wrangel.

[1] In 1658, her brother King Charles told her that he wished to make her spouse Lord High Chancellor of Sweden, but she convinced him not to by saying that Magnus Gabriel was more suited for military work.

He promised her great estates in Denmark, pensions for her children, and told her that he had named her consort Lord High Chancellor of Sweden in his will against her wish.

This matters were not only small things, they also concerned women asking her to use her contacts to acquire offices of great political importance for their male relatives.

After she, by using her contacts, managed to get an audience in private with the King, however, she told him that she hoped Gyllenstierna was now in Hell, and the result was that her spouse was appointed Seneschal.

During the great reduction of her nephew King Charles XI in the 1680s, a lot of the property of the family was confiscated by the crown.

The King refused to pay for the funeral of her spouse, and to stop the creditors from inventorying her own personal possessions and jewelry as well.