María Jimena Piccolo was born on July 22, 1985, in Buenos Aires, Argentina.

María Jimena Piccolo began her career in television with an advertisement for Banco Río in 1991.

In August 2001, she makes a small participation in the youth television series Chiquititas.

In 2007, she was part of the cast of the television series Los cuentos de Fontanarrosa.

In 2017, she performed the play El Mundo de Stefy y vos.