In the following years, she studied with Campos Coelho at the Lisbon Conservatory, taking courses in composition, theory, and history of music.

Subsequently, she performed with major orchestras in Europe, America, Canada, Israel and Japan, interpreting works by Bach, Beethoven, Schumann, Schubert, Mozart, Brahms, Chopin and other classical and romantic composers.

[5] In 2023, she was given the Jean Gimbel Lane Prize in Piano Performance from the Bienen School of Music at Northwestern University.

Her many successful recordings include performances of the Moonlight and other sonatas by Beethoven, Le Voyage Magnifique (the complete impromptus of Schubert), nocturnes and other works by Chopin, and Mozart trios with Augustin Dumay (violin) and Jian Wang (cello).

[6] Gramophone selected her recordings of the Chopin nocturnes as the best version available: "I have no hesitation in declaring Maria João Pires—a pianist without a trace of narcissism—among the most eloquent master-musicians of our time."

At the time of her move, she commented that she had suffered much adverse publicity in Portugal due to her Belgais Centre project to help tackle the significant problem of underprivileged children, a project that the Portuguese Government helped to fund but publicly shied away from.