[5] Konnikova worked as a producer for the Charlie Rose Show, where she helped to set up the segment "Brain Series.

"[5][10] She wrote the "Literally Psyched" column for Scientific American[11] and the psychology blog "Artful Choice" for Big Think.

[17][15] Her book The Confidence Game was published in 2016 and appeared on the New York Times' Crime and Punishment bestseller list.

In an interview with The New York Times, Konnikova stated that her motivation was not rooted in gambling, but in understanding the psychological aspects of the game.

In January 2018 she won the PCA National event in the PokerStars Caribbean Adventure No-Limit Hold'em Championship, earning a cash prize of $84,600.

[25] After her win in 2018, Konnikova delayed work on her book The Biggest Bluff in order to compete in more tournaments with higher stakes[23] and she became a full-time professional poker player.