Thayer has also had supporting roles in the comedy films Hitch (2005), Accepted (2006), and Forgetting Sarah Marshall (2008).

[6] Thayer and McBrayer reunited on an episode of 30 Rock in which she portrays Kenneth Parcell's blind, shallow love interest.

[1] Thayer stars in the Adult Swim comedy series Eagleheart,[6] which began airing on February 3, 2011, on Cartoon Network.

[9][10] In 2014, Thayer played the sudden wife of Forrest MacNeill (Andy Daly) on the Comedy Central show Review for the episode "Marry, Run, Party" of the first season.

Starting in 2015, she starred in the TruTV sitcom Those Who Can't as an incompetent teacher at a Denver high school, alongside Ben Roy, Adam Cayton-Holland and Andrew Orvedahl (The Grawlix).