Maria Theresa and her siblings were given a somewhat different upbringing than was usual for royal children at the time: they were actually raised by their parents rather than a retinue of servants, were largely kept apart from any ceremonial court life and were taught to live simply and modestly.

Mozart's opera Don Giovanni was originally intended to be performed in honor of Maria Theresa and Anthony Clement for their visit to Prague on 14 October 1787, as they traveled between Dresden and Vienna, and librettos were printed with dedication to them.

She was also present in Prague in September 1791 for the premiere of Mozart's opera La clemenza di Tito, which was written as part of the celebrations there in honor of the coronation of her father as King of Bohemia.

[3] Maria Theresa was described as a simple and homely character devoted to a private family life, and she was reportedly relieved to marry a spouse who was, at the time of their marriage, not expected to succeed to a throne.

[5] Maria Theresa assisted her father, by then Holy Roman Emperor, to arrange the meeting between Austria, Prussia and the French émigrées in Saxony, which resulted in the Declaration of Pillnitz 25 August 1791.