Admired for her vivid character portrayals and expressive singing, Zamboni was a popular and frequent performer at both La Scala and the Teatro Costanzi.

She studied at the Conservatorio di Musica Arrigo Boito in Parma under Guilio Silva before making her professional opera debut in 1921 at Piacenza as Marguerite in Gounod's Faust.

She sang regularly at the Teatro Costanzi from 1922–26 and 1929–30; most notably singing the role of Maria in the 1930 world premiere of Pizzetti's Lo straniero.

She toured South America frequently during the 1920s appearing in operas in Rio de Janeiro, Montevideo, São Paulo and Santiago.

[2] In 1936 Zamboni retired from the stage shortly after appearing as both Liu in Turandot and in the title role of Mario Persico’s Morenita at the Teatro San Carlo.