On September 4, 1916, during the formal dedication, St. Mary's became the first English-speaking Catholic school in the Panther Valley.

Classes in the school building began in 1924 under the guidance of the Sisters, Servants of the Immaculate Heart of Mary.

The current Marian Catholic High School building was dedicated on August 23, 1964, by Bishop Joseph McShea.

Mauch Chunk Catholic had begun in 1891, also under the direction of the Sisters, Servants of the Immaculate Heart of Mary.

From 1944 until 1953, this combined football squad played Catholic (or other private) high schools exclusively.