Mariana Engracia de Toledo Portugal y Pimentel (1623-1686), was a Spanish courtier.
[1] She was born to Fernando Álvarez de Toledo y Portugal, 6th Count of Oropesa, and Mencía María Alfonso-Pimentel y Zúñiga.
Her brother was Duarte Fernando Álvarez de Toledo, Viceroy of Navarre, Valencia and Sardinia.
She married her cousin Pedro Fajardo y Alfonso-Pimentel, 5th Marquis of Los Vélez (d. 1647).
She strengthened her position by forming a mutual alliance with the Queen's Jesuit prime minister Juan Everardo Nithard.