Izco began his career in the regionalised 3rd division of Argentine football with Club Atlético San Telmo, in 2000.

In his first season with Catania, Izco made 19 appearances in the league under then-coach Pasquale Marino, helping his team to a 13th-place finish.

Since his debut in 2006, Izco has been one of Catania's most valuable players throughout his stint at the Sicilian club, consistently being featured in the starting lineup.

[2] On 9 September 2020 he returned to Catania and signed a one-year contract with the club holding an option to extend it for another year.

[3] On 9 April 2022, he was released together with all of his Catania teammates following the club's exclusion from Italian football due to its inability to overcome a number of financial issues.