Some of her film credits include performances in Lovers (1991), Belle Époque (1992), Lucky Star (1997), Y tu mamá también (2001), Pan's Labyrinth (2006), The Blind Sunflowers (2008), Tetro (2009), Snow White (2012), and Abracadabra (2017).

Her first television opportunity was given to her at 13, featuring in the anthology series La huella del crimen,[1] directed by Vicente Aranda in the episode "Captain Sánchez's Crime".

Thereafter, she worked with such directors as José Luis Garci in Cradle Song; Bigas Luna in Golden Balls; again with Trueba in the Academy Award winner Belle Époque; Emilio Martínez-Lázaro in Backroads; Carlos Saura in Goya in Bordeaux; and Gonzalo Suárez in The Goalkeeper and Oviedo Express.

Verdú's performance in drama Lucky Star (1997) earned her another goya award nomination; she played one-eyed pregnant Marina, in a love triangle with a gelded butcher and a handsome criminal.

[4] She made her debut in an international work in Y tu mamá también (2001),[5] portraying Luisa Cortés, an exotic madrileña who ends up accepting a trip offer across rural Mexico from a Mexican cousin-in-law and his friend.

[12] Verdú's portrayal of Encarna (the evil stepmother) in black-and-white and silent drama film Snow White (2012) won her a second Goya Award.

[21] She also portrayed Carmen, a toxic mother and bon vivant, in season 7 of teen drama series Elite,[22] and the girlfriend and advisor of Leo (Daniel Giménez Cacho) in Familia.

[23] In 2024, she was reported to have joined the shooting of Max series Cuando nadie nos ve, set to star as Lucía Gutiérrez (a Guardia Civil agent investigating a suicide case in Morón de la Frontera) alongside Dani Rovira, Mariela Garriga, Austin Amelio, and Ben Temple.